Graphene-based actuators are of practical interest because of their relatively low cost compared with other nanocarbon materials, such as carbon nanotubes. We demonstrate the simple fabrication of graphene oxide (GO)based ﬁbers with an inﬁltrated nylon-6,6 polymer by wet spinning. These ﬁbers could be twisted to form torsional actuators and further coiled to form tensile actuators. By controlling the relative twisting and coiling direction of the GO/nylon ﬁber, we were able to realize reversible contraction or elongation actuation with strokes as high as −80 and 75%, respectively, when the samples were heated to 200 °C. The tensile actuation showed a remarkably little hysteresis. Moreover, this GO/nylon actuator could lift loads over 100 times heavier than itself and generate a stable actuation at high temperatures over the melting point of the polymer. This novel kind of GObased actuator, which has a multidirectional actuation, has potential for a wide range of applications such as artiﬁcial muscles, robotics, and temperature sensing.