Publications논문

Biomimetic cell-actuated artificial muscle with nanofibrous bundles
2022-01-26 14:42:38 조회수1281
Yongwoo Jang1, Sung Min Kim2, Eunyoung Kim1, Dong Yeop Lee1, Tong Mook Kang3 and Seon Jeong Kim1 1) Center for Self-Powered Actuation, Department of Biomedical Engineering, Hanyang University, Seoul 04763, South Korea 2) Department of Physical Education and Human-Tech Convergence Program(BK21 Four), Hanyang University, Seoul 04763, South Korea 3) Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, 16419, South Korea 원문 링크 : https://www.nature.com/articles/s41378-021-00280-z

Abstract

Biohybrid artificial muscle produced by integrating living muscle cells and their scaffolds with free movement in vivo is promising for advanced biomedical applications, including cell-based microrobotic systems and therapeutic drug delivery systems. Herein, we provide a biohybrid artificial muscle constructed by integrating living muscle cells and their scaffolds, inspired by bundled myofilaments in skeletal muscle. First, a bundled biohybrid artificial muscle was fabricated by the integration of skeletal muscle cells and hydrophilic polyurethane (HPU)/carbon nanotube (CNT) nanofibers into a fiber shape similar to that of natural skeletal muscle. The HPU/CNT nanofibers provided a stretchable basic backbone of the 3-dimensional fiber structure, which is similar to actin-myosin scaffolds. The incorporated skeletal muscle fibers contribute to the actuation of biohybrid artificial muscle. In fact, electrical field stimulation reversibly leads to the contraction of biohybrid artificial muscle. Therefore, the current development of cell-actuated artificial muscle provides great potential for energy delivery systems as actuators for implantable medibot movement and drug delivery systems. Moreover, the innervation of the biohybrid artificial muscle with motor neurons is of great interest for human-machine interfaces. 

 
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