Tissue-engineered vascular graft based on a bioresorbable tubular knit scaffold with flexibility, durability, and suture-ability for implantation
2023-01-06 14:40:10 조회수468
Dong Yeop Lee a†, Yongwoo Jang b†, Eunyoung Kim a, Tao Li a, Seon Jeong Kim a* a) Center for Self-Powered Actuation, Department of Electronic Engineering, Hanyang university b) Department of Pharmacology, College of Medicine, Hanyang university 원문 링크 :


The tissue-engineered vascular graft (TEVG) is a technology to recreate a blood vessel by using vascular cells (endothelial cells and smooth muscle cells) and their scaffolds, which is a promising approach to a clinically feasible alternative for small-diameter blood vessel replacement. Since mechanical damage occurs during/after implantation, it needs flexibility and durability to withstand the mechanical damage to be applied. To achieve this, we applied a bioresorbable polyglycolic acid (PGA) fiber-knitted tubular scaffold for vascular endothelial and smooth muscle cell layers. Similar to native rat aorta, the knitted tubular scaffold (130 μm-thick PGA fiber) exhibited mechanical performance at 150 mN up to 40% strain for axial stress and at 90 mN up to 5% strain for circumferential stress. After co-culture, a vascular barrier embodied in the inner layer of endothelial cells and outer layer of smooth muscle cells between tubular knits was observed. Up to 93.6% of the co-cultured cells were retained even after bending 50 times, and the suture-ability to flow liquid without leakage in various shapes, such as an L-shape or Y-shape, was acceptable. Taken together, these results support that the PGA tubular knit plays multifunctional roles, such as a porous three-dimensional matrix to attach and grow the vascular cells as well as a flexible and durable scaffold for the suture. Therefore, we suggest that the bioresorbable PGA tubular knit scaffold is a promising scaffold for TEVG for clinical vessel replacement. 

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