Controlled Magnetic Nanofiber Hydrogels by Clustering Ferritin
2008-10-11 10:42:16 조회수720
Min Kyoon Shin, Sun I. Kim, Seon Jeong Kim, Sang Yoon Park, Young Hoon Hyun, YoungPak Lee, Kyung Eun Lee, Sung-Sik Han, Dong-Pyo Jang, Young-Bo Kim, Zang-Hee Cho, Insuk So, Geoffrey M. Spinks (1) Center for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang UniVersity, Seoul 133-791, Korea (2) q-Psi & Department of Physics, Hanyang UniVersity, Seoul 133-791, Korea (3) School of Life Sciences & Biotechnology, Korea UniVersity, Seoul 136-713, Korea (4) Neuroscience Research Institute, Gachon UniVersity of Medicine and Science, Incheon 405-760, Korea (5) Center for Bio-Artificial Muscle and Department of Physiology, Seoul National UniVersity, Seoul 110-744, Korea (6) ARC Center of Excellence in Electromaterials Science and Intelligent Polymer Research Institute, UniVersity of Wollongong, Wollongong NSW 2522, Australia 원문 링크 :


We have fabricated biocompatible nanofiber hydrogels with diverse sizes of ferritin clusters according to the mixing
temperature of solutions employing electrospinning. Poly(vinyl alcohol) (PVA) was used as a polymeric matrix for
fabricating nanocomposites. By thermal means we controlled the interaction between the host PVA hydrogel and the
protein shell on ferritin bionanoparticles to vary the size and concentration of ferritin clusters. The clustering of ferritin
was based on the partial unfolding of a protein shell of ferritin. By studying the magnetic properties of the PVA/ferritin
nanofibers according to the mixing temperature of the PVA/ferritin solutions, we confirmed that the clustering process
of the ferritin was related to changes in the superparamagnetic properties and magnetic resonance imaging (MRI)
contrast of the PVA/ferritin nanofibers. PVA/ferritin nanofiber hydrogels with diverse spatial distributions of ferritin
nanoparticles are applicable as MRI-based noninvasive detectable cell culture scaffolds and as artificial muscles
because of their improved superparamagnetic properties.

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