Identification of TRPM7 channels in human intestinal interstitial cells of Cajal
2009-12-14 11:02:44 조회수584
Byung Joo Kim, Kyu Joo Park, Hyung Woo Kim, Seok Choi, Jae Yeoul Jun, In Youb Chang, Ju-Hong Jeon, Insuk So, and Seon Jeong Kim 1 School of Korean Medicine, Pusan National University, Yangsan 626-870, South Korea. 2 Center for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea 원문 링크 :


AIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract.

METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs).

RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La3+, TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue.

CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves.

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